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Nevertheless, across studies, lipid profile measures (total cholesterol, HDL-C, triglycerides), glucose, and insulin typically exhibit negligible or inconsistent variations, especially in short-duration interventions [102]

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Notably, ANGII-induced left ventricular hypertrophy and remodeling occurred both in the presence (Ichihara et al., 2001) or absence (Matsumoto et al., 2013) of hypertension, suggesting that hypertension may not be the primary mechanism by which ANGII induces cardiac remodeling