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Skin penetration remains the central unresolved question for topical products

10.1016/j.exer.2015.04.016 [DOI] [PubMed] [Google Scholar] Medvidovic-Grubisic M., Stambolija V., Kolenc D., Katancic J., Murselovic T., Plestina-Borjan I., et al

For topical use, transient local reactions redness, stinging, burning, or itch are the expected category and are exactly what the ongoing Phase 2 trial is set up to measure (NCT07437586)