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Drug Metab Dispos 18(5):765770 Roberts SA, Price VF, Jollow DJ (1990) Acetaminophen structure-toxicity studies: in vivo covalent binding of a nonhepatotoxic analog, 3-hydroxyacetanilide

Mutations in KARS, encoding lysyl-tRNA synthetase, cause autosomal-recessive nonsyndromic hearing impairment DFNB89

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Guanylate Cyclase Activation : The nitric oxide produced from L-citrulline activates guanylate cyclase, which synthesizes cyclic guanosine monophosphate (cGMP) that directly signals cardiovascular smooth muscles to relax and promote healthy blood flow