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It has been theorized that the combined molecular environment created by actin-related modulation and vascular-matrix signaling might support more complex insights into how organisms coordinate recovery or restructuring events

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However, perhaps inconsistent with this speculation is data from the pancreas suggesting that VIP increases muc5AC expression [118]

In agreement with these latter results, the work of Majors et al (1997) showed that a relatively low concentration of homocysteine (50 to 300 mol/L) stimulates collagen production in rabbit aortic smooth muscle cells that may favor extracellular matrix component accumulation in intimal lesions