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Beyond upregulating antioxidants, silybin exerts direct protective effects on the mitochondria themselves, which is vital for patients battling the profound fatigue and PEM associated with ME/CFS

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The dietary supplement protandim decreases plasma osteopontin and improves markers of oxidative stress in muscular dystrophy mdx mice

Consistent with their opposing immune responses, M1-polarized macrophages undergo a large-scale metabolic rewriting, accompanied by various metabolite changes compared with M2 macrophages [76, 77], which can be summarized in the following categories: (1) Interrupted TCA cycle, upregulated PPP, and other alterations damage OXPHOS, triggering ROS production