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Last, developmental studies investigating the effects of chronic stress converge on evidence that stress may impact brain maturational trajectory and rate, especially accelerating the maturation of affective-related circuits [86, 87], which may both represent an advantage in adverse conditions but may also limit plasticity and raise vulnerability to subsequent anxiety and affective disorders

22(1):5374 The somatomedin hypothesis and insulin-like growth factor signaling in endocrine regulation Yakar S, Liu JL, Stannard B, Butler A, Accili D, Sauer B, Le Roith D., Journal of Clinical Investigation , 2001

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Veterinary approval Always consult with your vet before starting any supplement