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Determining the ability of the test compound to bind to the NOVX protein can be accomplished, for example, by coupling the test compound with a radioisotope or enzymatic label such that binding of the test compound to the NOVX protein or biologically-active portion thereof can be determined by detecting the labeled compound in a complex

The organized matrix of bone marrow (BM) facilitates the proliferation and differentiation of hematopoietic cells, supported by stromal components including fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, and endothelial cells [32]

They present antigens, modulate T cell activation, and skew immune polarization toward Th17 and Th2 dominance, patterns commonly observed in autoimmune conditions

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