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American Journal of Obstetrics and Gynecology, 203(5), 481.e1-481.e5

Excessive TDP-43 can also induce mitochondrial DNA leakage into the cytosol, which activates NF-B and type I interferon pathways that drive neuroinflammatory responses (Yu et al., 2020)

(2) Translational Development: Research should accelerate the development of lung-specific delivery platforms (e.g., ligand-functionalized nanoparticles) for targeted ferroptosis intervention, moving from promising preclinical concepts toward clinical application