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[34] Unlike bidirectional and specific origin initiation of nuclear DNA replication, mitochondrial DNA has two strand-specific, unidirectional origins of replication of the leading H strand (O H ) which located in NCR and the lagging L strand (O L ) which located in the tRNA gene cluster

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Genetic alteration, inflammation, uncontrolled cell proliferation, and oxidative stress are important factors contributing to their progression (Tapia-Vieyra et al., 2017)