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4,5,7,21 This common pattern of dysbiosis typically manifests as the depletion of beneficial bacteria and the enrichment of harmful bacteria. Specifically, SCFA-producing bacteria, such as Faecalibacterium prausnitzii , Roseburia , and Butyricicoccus within the Lachnospiraceae and Ruminococcaceae families, are universally reduced in liver disease patients

Studies examining thymosin beta-4 biology also report roles in endothelial function and reparative cell activity, further connecting actin-regulated processes with vascular and regenerative signaling [7]

This includes the four core MMR genes as well as EPCAM, which may also harbor mutations in some cases ( The ESGO/ESTRO/ESP guidelines endorse MMR IHC as the preferred method for evaluating MMR status