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Jeong WJ, Choi SJ, Choi JS, Lim YB

10.1152/physrev.1990.70.2.427 221 PoberJ

Nucleic Acids Res (2008) 36:e141

While multiple published studies have drawn relationships between these SNPs and a wide variety of diseases, the American College of Medical Genetics has issued an official Practice Guideline recommending against testing or reporting on these two variants, citing "Recent meta-analyses have disproven an association between hyperhomocysteinemia and risk for coronary heart disease and between MTHFR polymorphism status and risk for venous thromboembolism