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On the one hand, with the continuous advancement of detection technology, the sensitivity and throughput of metabolomics detection will be further improved, which can more comprehensively reflect the metabolic status of patients

9b), we propose that accumulation of mut-p53 in cancer cells, through its repressive effects on NRF2 activity and SLC7A11 expression, creates an Achilles heel that can be exploited by further inhibition of system x C (Fig