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Immunohistochemistry for the cancer cell marker cytokeratin, the proliferation marker PCNA and the apoptosis marker TUNEL, revealed that HGF/c-MET inhibition per se had no effect on cancer cell number

However, as HF evolves, alterations of mitochondrial functions [3] and modulations of pyruvate metabolism (probably due to changes in PDH activity/expression, pyruvate transport and NADH shuttle [140]) occur and lead to a stage in which this switch is no longer adapted to support suitable energy production

and/or * Influencing, controlling or preventing conception in persons

It was shown to stimulate the proliferative capacity of epithelial cells (Khavinson et al 2003a, b) and fibroblast (Linkova et al 2016) in vitro thereby increasing the lifespan of the cells