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While the NIH does not specify a tolerable upper intake level for vitamin B12, a study published in the JAMA Network Open found that high intakes of vitamin B12, such as from daily supplementation of 25 micrograms or higher, increased the risk of bone fracture [3] [4]

Probiotics and antioxidants decrease irrational immune function and ROS-associated inflammatory responses modified by antioxidants (64) (Figure 2)

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Thus, ROS-induced vasoconstriction results in the pathogenesis of hypertension [14]