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Thesis, University of Oregon, Eugene

doi: 10.1016/j.freeradbiomed.2011.06.025

In vivo and in vitro studies have reported that EE itself is biotransformed for excretion mainly by glucuronidation (85%) and sulfation (12%) and that hydroxylation (mainly by CYP3A4 and CYP2A9 on C2) occurs only at low levels 22