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While it is usually harmless, lip pigmentation can impact ones confidence and facial aesthetics since lips play a major role in overall facial harmony and expression

Rangsimawong W, Opanasopit P, Rojanarata T, Panomsuk S, Ngawhirunpat T

It is possible that genetic alterations that change the permeability of the bloodbrain barrier (BBB) could either increase the accumulation of toxic substances in the brain or make it possible for toxic substances to enter the brain that are normally kept out