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When the signal reaches the end of the neuron, acetylcholine is released, spreading from the nerve to the muscle receptors

Early changes in skin quality or inflammation may be noticeable within a few weeks, while more visible improvements in texture, firmness, or hair typically emerge over 8 to 12 weeks

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Nonadherence: Patients may be nonadherent to their medication regimens due to experiencing real or perceived adverse effects and/or lack of benefit, complexity, burden, and cost