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This is more a contamination concern than a degradation concern, and it primarily affects compounded vials that have been at room temperature for extended periods

REDEFINE 2 showed 13.7% in T2D patients at 68 weeks

Integrative epigenomic analysis in differentiated human primary bronchial epithelial cells exposed to cigarette smoke

"The development of stable protein formulations: a close look at protein aggregation, deamidation, and oxidation." Critical Reviews in Therapeutic Drug Carrier Systems, 10(4), 307377. PMID: 8124728