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Choy 1,2 1 Head of Rheumatology and Translational Research Division of Infection and Immunity, Cardiff University School of Medecine, Cardiff, United Kingdom, 2 Director of the Cardiff Regional Experimental Arthritis Treatment and Evaluation (CREATE) Centre, Cardiff University School of Medicine, Cardiff, United Kingdom Non-steroidal anti-inflammatory drugs (NSAIDs) are broadly recommended by treatment guidelines as a pharmacological option for the symptomatic relief of osteoarthritis

In addition to its function as a leucine sensor, SESTRIN2 is a stress-inducible antioxidant protein and one of the upstream AMPK activators 269 (Fig