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We suggest that Mg 2+ has a selective regulation of Akt-dependent processes that is cell-specific and differ in adipocytes compared to skeletal muscle ( The exact metabolic exertion of Mg 2+ remains to be elucidated, but it is suggested that Mg 2+ and ATP act together in the IR-PI3K-Akt pathway as a kinase substrate ( 2+ may induce an electrostatic interaction, which enhances the binding affinity and stability of ATP to protein kinases ( 2+ -binding motifs ( The impaired glucose uptake caused by low intracellular Mg 2+ affects the metabolism of the adipocyte

doi: 10.1016/j.cell.2009.04.037 60 VousdenKHRyanKM