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IL interleukin, TLR-4 toll-like receptor, TNF-a tumor necrosis factor a, COX-2 cyclooxygenase-2, MCP-1 monocyte chemoattractant protein-1, CXCL C-X-C chemokine receptor, TGF-b transforming growth factor b, SOD-2 superoxide dismutase 2, NF-kB nuclear factor kappa-light-chain-enhancer of activated B cells, STAT1 signal transducer and activator of transcription 1, PPAR-g peroxisome proliferator-activated receptor g, TEER transepithelial electrical resistance, IgA immunoglobulin A Effects on the intestinal epithelium and mucosal barrier The intestinal barrier comprising the epithelium, mucus layer, and tight-junction complexes serves as the primary defense against pathogen and antigen translocation into the lamina propria

After that, it begins a slow, steady decline