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Studies have reported that the use of bisphosphonates can delay bone metastasis in patients with breast cancer and improve overall survival (36,37)

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doi: 10.3390/cancers11070931

For example, inhibitors targeting histone demethylases (such as KDM5 inhibitors like CPI-455 or ryuvidine) have demonstrated efficacy in preclinical models by preventing the reversible repression of chromatin states necessary for DTP survival ( 4.2 Exploiting metabolic vulnerabilities of DTP cells Metabolic reprogramming observed in DTP cells provides another therapeutic opportunity