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Description

The catalytic core of class II ARS is comprised of seven anti-parallel sheets flanked by -helices and harbors three conserved motifs [7, 8, 18]

In the absence of an appropriate compensation by the endogenous antioxidant defense network, increased oxidative stress leads to the activation of stress-sensitive intracellular signaling pathways and the formation of gene products that cause cellular damage and contribute to the late complications of diabetes [3,4]