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Given the progressive nature of the disorder, disease pathogenesis is mainly triggered by continual processes such as geometric accumulation of oxidative radicals brought about by cellular inclusions and mitochondrial dysfunction 8,9,10

Clinical research has indicated that FOXO4-DRI has shown promise in the following areas: Targets senescent cells FOXO4-DRI is a synthetic peptide designed to target senescent cells, which are damaged cells that stop dividing but resist apoptosis (programmed cell death)

The rhizobium meliloti exoK gene and prsD/prsE/exsH genes are components of independent degradative pathways which contribute to production of low-molecular-weight succinoglycan