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Since S-adenosyl homocysteine (SAH) is both a product and potent inhibitor of methylation reactions, the SAM/SAH ratio is considered a useful indicator for proper methylation (Tyagi et al ., 2005)

Journal of Laboratory and Clinical Medicine, 140(6), 413-417

Biochemistry 34 , 65216526 (1995)

Given the plasma concentration curve, the plasma concentration-time information for drugs can be fitted using the nonlinear least square technique, and some important pharmacokinetic data (pharmacokinetic half-life, plasma maximum, minimum blood concentration, bioavailability of drugs) are available