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112 Other functional changes characterized by the bacterial dysbiosis typical of the condition are elevated branched-chain amino acid metabolism, along with elevated methane metabolism, enhanced degradation of xenobiotics and stimulated sulphate reduction

Consequently, choline and betaine methylated the promoter region of PPAR-, suppressing mRNA expression and possibly the lipogenic actions of the encoded protein

141,142 Thus, a number of authors have examined the possibility that metformin might be the cause of a vitamin B 12 deficiency and subsequently directly responsible for peripheral neuropathy in T2DM patients

doi:10.1111/j.1365-2141.1968.tb01486.x