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In addition, we investigated the metabolic fate of U- 13 C glutamine, which produces -GC and GSH containing five 13 C atoms via GSH de novo synthesis (Fig

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We have also shown that induction of melanogenesis in melanoma cells leads not only to increased HIF-1 accumulation but also to the robust upregulation of HIF-1-dependent and independent pathways, suggesting a role for melanogenesis in the regulation of cellular metabolism and behavior of melanoma cells ( Figure 3 ) (207)

doi: 10.1084/jem.20102392 106 ItoMMinamiyaYKawaiHSaitoSSaitoHNakagawaTet al