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Even transient exposure to hyperoxia triggers persistent mitochondrial dysfunction, characterized by metabolic reprogramming (e.g., impaired oxidative phosphorylation) and structural disorganization, which collectively disrupt alveolar development (Garcia et al., 2021)

Energy-restricted, n-3 polyunsaturated fatty acids-rich diet improves the clinical response to immuno-modulating drugs in obese patients with plaque-type psoriasis: a randomized control clinical trial

A report demonstrated that even after systemic injection of platinum-based anticancer drugs in a homologous melanoma model, 50 nm polymer micelles can still target lymph node metastasis and inhibit the growth of metastatic lesions, whereas larger nanocarriers cannot penetrate the metastatic site [68]