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Resveratrol, quercetin, and apigenin have been reported to neutralize ROS and upregulate antioxidant enzymes like superoxide dismutase (SOD) and heme oxygenase1 (HO 1 ) in cellular PD models [39, 62]

doi: 10.1016/S0076-6879(01)35230-8 584 GuLKelmMAHammerstoneJFBeecherGHoldenJHaytowitzDet al

The findings have been variable

Among naturally occurred inhibitors, sesquiterpenoids with an ,-unsaturated lactone moiety have great potentials because they covalently bind to amino acid residues Cys46 and Cys179 of IKK