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Although leg cramps are not listed as an official adverse effect in FDA prescribing information, understanding the potential indirect mechanismsincluding dehydration, electrolyte imbalances, and nutritional changescan help patients and clinicians address this symptom effectively while continuing therapy

However, these results are contradictory to some previous studies that reported inverse associations of smoking with hyperuricemia and gout, particularly in males, but no associations in females 7-9