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Melanotan II was investigated clinically but never reached approval

14 Other entities in the differential include secondary syphilis, which commonly presents as macules and scaly papules and can be found on mucosal surfaces such as the oral cavity, 15 as well as Kaposi sarcoma, which is characterized by purplish, brown, or black macules, plaques, and nodules, more commonly in immunosuppressed patients

This combination may also help address conditions like vitiligo or photosensitivity more effectively, offering both aesthetic and functional improvements

Melanocytic nevi are included in the differential diagnosis of melanosis and melanoma and are often detected in younger patients