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Currently, the detection of ferroptosis in cells is also based on ferroptosis morphology and metabolic alterations

Triggered by an extrinsic or an intrinsic pathway, caspase-induced PCD culminates with the formation of apoptotic bodies that are eliminated by adjacent phagocytes 74

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Moreover, the BRCA1 loss mutation, like oncogene activation (RAS, NF-B, TGF-), in cancer cells will drive the initiation of metabolic symbiosis phenotype between tumor cells and fibroblasts in both primary and metastatic cancers (226)