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Mounjaro (tirzepatide) was initially FDA-approved in 2022 for type 2 diabetes

The sole cellular iron exporter, ferroportin (FPN, encoded by SLC40A1), exerts protective effects by maintaining iron homeostasis through MTF1-mediated transcriptional activation

it modulates immune responses while maintaining cellular homeostasis by coordinating the mitochondrial-ER interaction network, providing important insights for developing novel metabolic immunomodulators from traditional medicines (93)