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Conversely, the surge of Th1-associated cytokines (IFN- and TNF-) in gsh2- infected mice at the experimental endpoint suggests enhanced inflammation that may damage lungs and exacerbate disease 43 (Extended Data Fig

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This is in agreement with previous work indicating that TMZ resistance in glioma is associated with lower production of reactive oxygen species by the resistant cell line, 15 although this does not exclude the possibility of a scavenging action of GSH also for TMZ