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However, chronic NOX overactivation can disrupt redox balance, leading to synaptic damage, neuronal apoptosis, and cognitive deficits, thereby contributing to the progression of EDC

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The IRP1-HIF-2 axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption

The GM also suppresses hepatic lipid synthesis through BA and modulating the gene expressed through the FXR signaling pathway (Iruzubieta et al., 2020)