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Somewhere between 500mg and 5000mg per day is usually the perfect amount to heal leaky gut and increase glutathione without overdoing the glutamate

Goedecke JH, Elmer-English R, Dennis SC, Schloss I, Noakes TD, Lambert EV

The current concern is that excessive or inappropriate antioxidant interventions in aging CAP instead disrupt normal cell signaling pathways and inhibit the beneficial effects of ROS and lipid peroxidation products on disease, such as by mediating the physiological apoptosis of immune cells (213)

Moreover, as with KRAS-selective inhibitors, resistance to pan-RAS inhibitors emerges rapidly, raising concerns about the durability of benefit