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Complex interactions among these proteins and their associated regulators were illustrated in a PPI network containing 56 nodes and 426 edges (Figure 3B)

How This Works Des(13) IGF1 is a truncated IGF1 analog designed/observed to: Retain affinity for IGF1 receptor (IGF1R) Interact differently with IGF binding proteins (IGFBPs), often described as lower binding, which can increase free fraction in experimental settings

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