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The intestinal mucosal injury and associated changes in the intestinal microbiome provide the backdrop for the inflammatory processes

Mateer SW, Maltby S, Marks E, Foster PS, Horvat JC, Hansbro PM, et al

further highlight the necessity to broaden the research spectrum to encompass additional musculoskeletal disorders, enriching our understanding of ozone therapy applications in orthopaedics [18]

Nociceptive neurons are endowed with a series of receptors, such as innate immune system receptors, like Toll-like receptors (TLR), which can directly detect the presence of a pathogen and send danger signals to the immune system, for instance through the secretion of neuropeptides that activate immune cells