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Patients with multifocal disease (especially if more than three lesions) or nodal disease (especially if extraregional) are prone to early recurrence post-surgery, suggesting a limited benefit from the procedure 246,247,248

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To determine whether the ASXLs binding mechanism is conserved in BRD4 ET , we tested ASXL2 EBM (aa 615-628 of ASXL2) and ASXL3 EBM (aa 10081021 of ASXL3) peptides in 1 H, 15 N HSQC titration experiments and fluorescence spectroscopy (Fig