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This also highlights the potential influence of tumor metabolic status (e.g., glycolysis activity) on cuproptosis sensitivity low LDH levels correlate with impaired glycolysis and enhanced mitochondrial metabolism, thereby fostering the metabolic dependencies of cuproptosis

There can be weakness, numbness or pins & needles in the leg

Simultaneously, prolactin can induce leptin resistance, further disrupting the central energy homeostasis

Unlike physiological aging, which unfolds over decades, inflamm-aging is characterized by the activation of pro-inflammatory mediators, such as IL-6, TNF-, and chemokines, which can induce follicular atresia, compromise steroidogenesis, and hasten menopause (Yan et al., 2022)