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The first of these drugs, cimetidine, was developed by James Black (figure 27), a Scottish physician and pharmacologist with a long-standing interest in the gut and the challenge of treating gastric and duodenal ulcers

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Collectively, the results in this section indicate that metabolic imaging of PGLS activity using hyperpolarized -[1- 13 C]gluconolactone has the ability to provide an early readout of response to TMZ that precedes the onset of MRI-detectable tumor shrinkage