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10.1042/bj3320097 Biochem

This study involved 100 adults with halitosis, randomly assigned to either the test group ( n = 50) or the control group ( n = 50)

Inhibition of CYP51A1 with ketoconazole has demonstrated diverse biological effects: it rescued EGFR degradation in A431 carcinoma cells by blocking sterol metabolism upstream of MSMO1, and reduced inflammatory signaling and cytokine release in mouse macrophages, ultimately improving survival in a model of endotoxic shock

What appears to be consistent in the above triggers of CFS is that they initiate excessive amounts of inflammation and oxidative stress, which has a direct impact on mitochondrial function