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62 In addition, after fluoxetine-mediated stimulation of the 5-HT 2B receptor in astrocytes, epidermal growth factor receptor (EGFR) is transactivated and subsequently activates the MAPK/ERK and PI3K/AKT signaling cascades, which control the expression of mRNA or proteins that may be linked to mood disorders, such as SERT

Interestingly, most ligand interactions with TRF1 TRFH (12/19 ligands) involved the side chains of R131 or Q127, whereas only three fragments formed direct interactions with the more flexible R102 and E106 residues