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For example, DFP and NAC monotherapy showed similar cardioprotective effects, however, the combination of DFP with NAC showed more significant effects in reducing cardiac iron deposition and cell apoptosis compared to monotherapy ( Gene therapy Gene therapy is a potentially curative treatment for transfusion-dependent thalassemia ( HSCT is the only definitive possible cure for patients with -TM ( Xenogenic stem cell suppression is based on the use of autologous hematopoietic stem cells to overcome complications that can be a limiting factor in allogeneic HSCT, such as donor availability, risk of infections, graft rejection, and graft-vs.-host disease (193)