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It is my understanding that Phase 4 trials study specific populations with pre-existing conditions, although whether or not we ever get there remains to be seen

As IFN- is known to increase paracellular permeability through disruption of TJs (223)

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Among the progeny, we characterized the homozygous mutant rats with deletion of CACGC (designated as Tshr Df/Df ) and used them for the following experiments