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doi: 10.5455/apd.53708

Polar compounds cannot diffuse across these cell membranes, and the uptake of useful molecules is mediated through transport proteins that specifically select substrates from the extracellular mixture

If you're taking any of the following long-term, it may be worth discussing nutrient monitoring with your healthcare provider: Acetaminophen (Tylenol) Glutathione Statins CoQ10, Magnesium Birth Control Pills B Vitamins, Vitamin C, Zinc, Magnesium Metformin Vitamin B9 (Folate), Vitamin B12, CoQ10 Benzodiazepines Melatonin SSRI Antidepressants Vitamin B6, Vitamin B9, Vitamin B12, Essential Fatty Acids Proton Pump Inhibitors (PPIs) Vitamin B12, Vitamin C, Iron, Calcium, Magnesium Corticosteroids Vitamin B9, Vitamin C, Zinc, Vitamin D, Selenium, Magnesium Important: Nutrient depletion varies based on the individual, dosage, duration of use, diet, and overall health

Another example of how NAC can help with detoxification is in dentistry