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In contrast, rats injected with iohexol exhibited diminished CT signals, lacking contrast enhancement at elevated radiation energies (Figure S10B)

Single-guide RNA (sgRNA) sequences targeting STK38, RIPK1, and MEKK2 were designed using the CRISPOR web tool ( The sgRNA primer pairs used were as follows: sgSTK38 #3: forward 5-CACCGGTTCTTCATGTTGAGCGATA-3, reverse 5-AAACTATCGCTCAACATGAAGAACC-3

Functional impairments in structures such as the orbitofrontal cortex of the brain, the limbic system, basal ganglia, and thalamus are thought to occur in the etiology of OCD, and neurotransmitters such as the dopamine and serotonin system and various neuropeptides have been implicated in these disorders (3)

10 , e2206893 (2023)