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ArticlesVolume 363, Issue 9418p1346-1353April 24, 2004 Download Full Issue Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis Dr Andrew G Renehan, PhDa [email protected] Marcel Zwahlen, PhDc Prof Christoph Minder, PhDc Sarah T ODwyer, MDa Prof Stephen M Shalet, MDb Prof Matthias Egger, MDc,d Affiliations & NotesArticle InfoLinked Articles (1) Summary Background Insulin-like growth factor (IGF)-I and its main binding protein, IGFBP-3, modulate cell growth and survival, and are thought to be important in tumour development