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Similarly, the Ma research team used the same strategy to prepare CFP2-C-5-FU-FA NPs, and confirmed through in vivo fluorescence imaging technology that the fluorescence signal intensity of the targeted nanoparticles in the tumor region was significantly higher than that of the non-targeted control group, and had lower cardiac toxicity (Figure 3C)

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Considerable debate has focused on whether H 2 O 2 generated within the mitochondrial matrix can be released into and impact other cellular compartments 12