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Furthermore, because oxygen radicals can release iron from iron-sulfur clusters, factors that promote regeneration of iron-sulfur clusters can also play a role in recovering from oxidative damage

Although in both disorders the immune response is different, genetically susceptible individuals have an inappropriate mucosal immune response against their gut microbiota, mediated by an excessive activation of effector T cell subsets and/or a deficiency of Treg cells (65) (Figure 1A)

PD-1(+) regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

It also reduced pro-inflammatory cytokines (IL-6, TNF-, IFN-) and the expression of the p38 MAPK pathway